Rapid Identification and Determination of Etamsylate Injection by Raman Spectroscopy

OBJECTIVE To develop a method for the rapid identification and determination of Etamsylate injection using Raman spectra. METHODS Raman spectra was used as the method of identifying and determination the Etamsylate injection. Determination conditions: Micro Raman spectroscopy, Laser: 785 nm, Objective: 50×, Laser power: 3 mW, Signal acquisition time: 60 s. RESULTS The result showed that the Raman spectroscopy could identify Etamsylate injection and determinate Etamsylate injection in respectively 98.29%, 97.56%, 100.21%(Specifications: 2 mL∶0.5 g)and 98.75%, 94.98%, 96.25% (Specifications: 2 mL∶0.25 g), the results of determination results with the HPLC method showed no significant difference. CONCLUSION Owing to its fast and nondestructive properties, the presented method can be developed as an analysis method for Etamsylate injection.