Synthesis of Rupatadine fumarate

OBJECTIVE To synthesis rupatadine fumarate and optimize the reaction conditions. METHODS Rupatadine fumarate was synthesized from 5-methyl nicotinic via esterification, reduction, chlorination, alkylation and salification. RESULTS The rupatadine fumarate was synthesized with a total yield of 46.4% and its structure was confirmed by 1H-NMR, MS and IR. CONCLUSION The synthetic route is suitable for production of rupatadine fumarate in industry.