Determination of Residual Oganic Solvents in Lumefantrine by Headspace Capillary Gas Chromatography

OBJECTIVE To establish a method of head-space capillary gas chromatography(GC) for the determination of residual organic solvents in lumefantrine. METHODS Residual organic solvents in lumefantrine were separated on DB-624 capillary column using temperature programming and nitrogen as the carrier gas. The inlet temperature was 250 ℃. FID was used as detector with a temperature of 200 ℃. RESULTS Six residual organic solvents were completely separated. There was a good linearity in the experimental concentration ranges(r=0.999 9-1.000 0). The RSD of precision was less than 10%. The average recovery rate ranged from 99.3% to 101.5%. The detection limits were between 0.173 and 0.396 μg·mL^-1. CONCLUSION The method is rapid, sensitive and accurate, which can be used for quality control for the determination of residual organic solvents in lumefantrine.