A Case Study of the Association Between Genetic Polymorphisms and Interindividual Variation of Response to Rosuvastatin

OBJECTIVE To explore the possible reason of that a patient had decreased short-term lipid-lowering response to rosuvastatin. METHODS The patient’s ATP-binding cassette G2 (ABCG2) and organic anion transporter 1B1 (SLCO1B1) gene polymorphisms was detected. Pyrosequencing technology was used to detect gene polymorphisms. RESULTS The patient was ABCG2 c.421 CA heterozygous, SLCO1B1 c.388GG homozygous, SLCO1B1 c.521TT homozygous. CONCLUSION SLCO1B1 c.388G mutation may be related to decreased short-term lipid-lowering response to rosuvastatin.