In Vitro Release Investigation of Breviscapine Microemulsion-based Gel

OBJECTIVE To investigate in vitro release of breviscapine microemulsion-based gel. METHODS The positive and reverse dialysis bag techniques were performed to measure the in vitro release of breviscapine microemulsion gel, PBS(pH 6.8) was the release medium. RESULTS Breviscapine was released more rapidly by reverse dialysis bag technique than the positive one. The reverse dialysis bag technique showed that it released above 60% within 2 h, beyond that, it released above 90% at 10 h. The optimal process fitting one-order kinetic mechanism. CONCLUSION The reverse dialysis bag technique could preferably simulate the release behavior of breviscapine microemulsion gel. The characteristic of in vitro release of breviscapine microemulsion-based gel is good.