Progress of Aurora Kinase and Its Inhibitors

OBJECTIVE To introduce the research progress of Aurora kinase and its inhibitors based on their structures. METHODS To summarize the chemical scaffold , the common binding modes, and the clinical progress of Aurora kinase inhibitors. RESULTS & CONCLUSION The Aurora kinase had emerged as an attractive target for cancer therapies. The adenosine mimic scaffolds could be used for further study to design addtional potential inhibitors of Aurora with high inhibitory activity.