Comparison of the Pharmacokinetics Between Glycyrrhizic Acid Phospholipid Complex Self Emulsifying Capsule and Enteric Coated Capsule

OBJECTIVE To compare the pharmacokinetics between glycyrrhizic acid phospholipid complex self emulsifying preparation(T) and glycyrrhizic acid diammonium enteric coated capsule(R) in dogs. METHODS Six Beagle dogs were given orally T and R, with a single dose of 50 mg·kg^-1 glycyrrhizic acid in self crossover study. The plasma concentration of glycyrrhizic acid was assayed by HPLC and the pharmacokinetic parameters were calculated with DAS2.0 program. RESULTS T_max for R and T were (6.00±0.000)h and (2.917±0.585)h; C_max for R and T were (12.756±1.075)mg·L^-1 and (17.751±1.604)mg·L^-1, respectively; AUC_0-t were (150.894±22.850)mg·h·L^-1 and (211.196±40.880)mg·h·L^-1; AUC_0-∞ were (159.39±21.862)mg·h·L^-1 and (221.287±42.164)mg·h·L^-1; the relative bioavailability of T was 139.76%. CONCLUSIONS The pharmacokinetics of glycyrrhizic acid in dogs accorded with the two compartment models and with the first-order absorption after T or R administration orally, C_max, AUC_0-t and AUC_0-∞ of T were all higher than those of R, and T had a higher bioavailability, which reached the object of this task.