Degradation Pathway of Ambroxol Hydrochloride in Fructose Infusion

OBJECTIVE To study the degradation pathway of ambroxol hydrochloride injection in fructose infusion. METHODS The structures of degradation products of ambroxol in fructose infusion was elucidated by MS. RESULTS The degradation product of ambroxol in fructose infusion was trans-4-(6,8-dibromo-1,4-dihydroquinazolin-3(2H)-yl)cyclohexanol. Impurities produced were related to fructose degradation. CONCLUSION The structure of degradation product of ambroxol in fructose infusion has elucidated, and the pathway has revealed.