Study on the Dissolution Test of Captopril Tablets in Chinese Pharmacopoeia 2010

OBJECTIVE To improve the dissolution determination method of captopril tablets. METHODS The new established dissolution determination method was the basket method. The 0.01 mol·L^-1 hydrochloric acid of 900 mL was used as the dissolution medium, the rotation speed was 50 r·min^-1 and the time was 20 minutes. RESULTS According to the USP dissolution test on sample of manufacturer A and B, the difference of dissolution curves was obvious. In addition, the sample of manufacturer B was unqualified and the uniformity of within-lot was bad. CONCLUSION The improved method inhibites the degradation of captopril. It provides a reference for the quality control of captopril tablets, and can be used for the dissolution test of captopril tablets.