Total Synthesis of Martynoside

OBJECTIVE To synthesis the natural phenylpropanoid glycoside, martynoside. METHODS Using D-glucose as the starting material, martynoside was successfully synthesized via acetylation, bromination, etherification, removing acetyl, introducing protective groups and substituted rhamnose, removing benzylidene, acylation, and removing protective groups. RESULTS The chemical synthesis of the phenylpropanoid glycoside martynoside was realized for the first time. Its structure was identified by 1H-NMR, 13C-NMR and MS spectroscopy, as well as by elemental analysis. CONCLUSION The starting materials are easy to get and the method is feasible.