Effects of Fluoxertin on the Ethology and Apoptosis of Hippocampal Neurons in Rats with Post-stroke Depression

OBJECTIVE To discuss the effects of fluoxertin as the representative of SSRIs on the ethology and apoptosis of hippocampal neurons in rats with post-stroke depression(PSD). METHODS The focal cerebral ischemia novel model was set up by blocking the middle cerebral artery(MCAO) and then the rats in model group were separately raised and put into chronic unpredictable mild stress(CUMS) forinducing the PSD mode1. Rats in PSD+fluoxertin group were administrated 10 mg·kg^-1 fluoxertin, ip. Weights, sugar-water consumption, locomotor activity and apoptosis rate of hippocampal neurons were detected respectively. RESULTS On the 14th day after CUMS, the PSD group showed significantly less weights, locomotor activity and sugar-water consumption( P <0.05 or P <0.01) and higher apoptosis rate of hippocampal neurons compared with the PSD+fluoxertin group( P <0.01). CONCLUSION Fluoxetine is effective for the treatment of PSD．