Efficacy of Paliperidone Extended-release Tablets for the Psychiatric Symptoms and Life Quality in Patients with Alcohol-induced Mental Disorders

OBJECTIVE To study the efficacy and safety of Paliperidone Extended-release tablets in the treatment of alcohol-induced mental disorders. METHODS Fifty cases of alcohol-induced mental disorders were randomly divided into the study group and the control group. In study group, patients were treated with Paliperidone Extended-release tablets, while in control group, patients were treated with haloperidol. The study period was 6 weeks. After 1, 2, 4, 6 weeks of treatment, positive and negative symptom scale(PANSS), quality of life index questionnaire(QL-Index) and treatment emergent symptom scale(TESS) were assessed for all patients to evaluate the effect and adverse reactions. RESULTS The therapeutic effect rate of study group was 72%, while the control group was 60%, this difference was significant(P<0.05). PANSS scores in the study group decreased significantly from 1st week, while those in control group decreased starting from the 2nd week; QL-Index scores in the study group increased significantly from 1st week, while those in the control group increased from 2nd week. After treatment of 1, 2, 4, 6 weeks, the scores of PANSS of the study group were lower than those in the control group, and the QL-Index scores of the study group were higher than those in the control group. The TESS scores in the study group were significantly less than that in control group after 1, 2, 4, 6 weeks. CONCLUSION Paliperidone Extended-release tablets is superior to haloperidol in the treatment of mental disorders duo to alcohol with better efficacy and safety.