Effect of Xinnaoning Tablets on the ATP Enzyme, LDH and CK Activity of the Rat Myocardial Ischemia Model

OBJECTIVE To study the effect of Xinnaoning tablets on the ATP enzyme, LDH and CK activity of rat myocardial ischemia model. METHODS The seventy rats of half male and half female were divided into seven groups. The first group was the control group, and the other six groups were made the model of myocardial ischemia. Six groups of rats were fed with different doses of Xinnaoning tablets suspension, nifedipine suspension, Nao-xin-tong capsule suspension, nifedipine suspension, Nao-xin-tong capsule suspension and the same volume of 0.5% CMC. The activity of ATP enzyme LDH and CK were observed, and the diog electrocardiogram was draw as well. RESULTS Compared with model group, three doses of Xinnaoning tablets groups, Nao-xin-tong capsule group and nifedipine tablets group could increase the Na⁺-K⁺-ATPase activity of myocardial tissue homogenate(P<0.01); medium and low dose of Xinnaoning tablets group could increase the Mg²⁺-ATPase activity of myocardial tissue homogenate(P<0.01 or P<0.05); low dose of Xinnaoning tablets group could increase the activity of Ca²⁺-ATPase in myocardial tissue homogenate(P<0.01). Compared with the model group, three doses of Xinnaoning tablets groups, Nao-xin-tong capsule group and nifedipine tablets group could significantly reduce the activity of serum LDH(P<0.01); High, medium and low doses of Xinnaoning tablets groups, Nao-xin-tong capsule group and nifedipine tablets group could decrease the activity of CK in serum(P<0.01 or P<0.05). Xinnaoning groups could reduce the elevation of ST segment. CONCLUSION Xinnaoning tablets group can significantly improve the activity of ATPase, reduce the activity of LDH and CK.