Comparison of Efficacy and Safety of Paliperidone and Risperidone in Treatment of Schizophrenia by Meta Analysis

OBJECTIVE To compare the efficacy and safety of paliperidone and risperidone in treatment of schizophrenia. METHODS Standard 16 studies were analyzed by evidence-based medicine, differences in efficiency, cure rate, scale score and adverse reactions of paliperidone and risperidone in the treatment of schizophrenia were evaluated. RESULTS There were significant differences in efficiency and scale score of paliperidone and risperidone in the treatment of schizophrenia. The incidence of extrapyramidal reactions, insomnia, lactation and menstrual disorders, abnormal liver function in paliperidone group was significantly lower than risperidone group. CONCLUSION Paliperidone is more effective than risperidone, and has lower incidence of adverse reactions.