Effects of Xylaria Nigripes Powder on Antioxidant System and Inflammation Factor in Experimental Atherosclerosis Rabbits

OBJECTIVE To observe the effects of Xylaria nigripes powder on antioxidant system and inflammation factor in experimental atherosclerosis rabbits. METHODS Atherosclerosis rabbits model were established, simultaneously continuously gives Xylaria nigripes powder 100 mg·kg^-1·d^-1 12 weeks, measured rabbit plasma total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), malondialdehyde (MDA), C-reactiveprotein (CRP), interleukin 6(IL-6), tumor necrosis factor-α(TNF-α) content, and the activities of superoxide dismutase(SOD) and gutathione peroxidase (GSH-Px). The pathomorphological changes of aorta were observed. RESULTS Administration of Xylaria nigripes powder could effectively reduce the thick of atherosclerotic plaques and decrease plasma content of TG, MDA and CRP (P<0.01), while rise the content of HDL-C and activities of SOD and GSH-Px(P<0.01). CONCLUSION Xylaria nigripes powder reduces the level of TG, increase the activities of antioxidant and inhibit the production of part inflammatory factor to reduce atherosclerosis.