Study on Preliminary Pharmacodynamics and Permeation of Monocrotaline Gels in Vitro

OBJECTIVE To study the permeation of monocrotaline gels in vitro and to observe its therapeutic effects of squamous cell carcinoma in mice. METHODS The permeation of monocrotaline gels was measured by using Franz diffusion cell. The therapeutic effects of monocrotaline gels was observed on the model of squamous cell carcinoma in mice. RESULTS The permeation of monocrotaline gels in vitro was very good. The monocrotaline gels could obviously inhibit the squamous cell carcinoma in mice, the tumor inhibitory rate was 35.26%. CONCLUSION The permeation of monocrotaline gels in vitro is very good, the monocrotaline gels can obviously inhibit the squamous cell carcinoma in mices.