Stability of Nitroprusside Sodium for Injection Compatibility with Solvent Multiple Factors and Levels Multicriteria

OBJECTIVE To research the best compatibility program of nitroprusside sodium for injection. METHODS L₁₆(4₃×2₆) of orthogonal design was used with five factors: temperature, solvent, solvent dosage, illumination and time; the content of sodium nitroprusside was detected by HPLC; the insoluble particles were observed by a GWF-5J type particle analyzer; the pH were observed by a pHS-2C precision acidity meter; the integrated brading method was used in selecting the optinum process. RESULTS The optinized processing was sodium nitroprusside 50 mg, dissolved in 250 mL sodium chloride injection, avoiding light, used in 26 h. CONCLUSION This scheme provides the scientific basis for the clinical medication.