Effect of Xinnaoning Tablets on Lactic Acid, LDH and ATP in Cerebral Ischemia Rats

OBJECTIVE To study the effect of Xinnaoning tablets on lactic acid, LDH and ATPase activity effect in cerebral ischemia rats. METHODS Wistar rats were randomly divided into 7 groups: control group, model, high- middle- and low-dose of Xinnaoning tablets group, nimodipine group, Naoan tablets group and 0.5% CMC group. The content of brain homogenate protein, LD, LDH, ATPase levels were determined. RESULTS The model of cerebral ischemia rats were established successfully. Compared with model group, high-, middle-, and low- dose of Xinnaoning tablets could significantly decrease LD, raise LDH, and elevate brain homogenates of Na⁺-K⁺-ATPase, Mg²⁺-ATPase activity and Ca²⁺-ATPase activity (P<0.01 or P<0.05). CONCLUSION Xinnaoning tablets have significantly improve effect on cerebral ischemia.