Study on Renal Protective Mechanism of Astragalus Polysaccharides on Hyperlipidemia Rats

OBJECTIVE To investigate the effects of Astragalus polysaccharides(APS) on rat renal cortex colipase high cholesterol, and preliminary study of renal protection mechanisms. METHODS Hyperlipidemia rat model was established by high fat diet. APS intraperitoneal administration for 8 weeks, serum Cr, BUN, TC, TG, kidney MDA, SOD, colipase and renal morphology were observed. RESULTS APS could significantly decrease serum Cr, BUN, TC, TG and renal tissue MDA, rise renal tissue SOD and renal colipase. Serum Cr had good negative correlation with renal colipase(r=-0.993 0). However, renal tissue morphology didn’t significantly improve. CONCLUSION APS has lipid antioxidant effect, can reduce lipid peroxidation product, so as to protect hyperlipidemia rat renal. The mechanism may be related to renal colipase expression promotion.