Study on the Inhibition of Experimental Atherosclerosis in Rabbits by Grape Seed Proanthocyanidin and Its Composition

OBJECTIVE To study the effect of grape seed proanthocyanidin and its compositions with tea polyphenol or curcumin on rabbit model of atherosclerosis. METHODS The rabbit model of atherosclerosis was established by high-fat diet. Rabbits were divided into six groups: normal control group, atherosclerosis model group, proanthocyanidin group, proanthocyanidin and tea polyphenol group, proanthocyanidin and curcumin group, and simvastatin group. After atherosclerosis rabbit model established, the rabbits were given proanthocyanidin compositions for four weeks. The blood-lipid level was measured. Hepatic tissue and aortic atherosclerosis were observed by transmission electron microscope and the Oil red staining. RESULTS Proanthocyanidin compositions significantly reduced the serum level of triglyceridethe, total cholesterol and low density lipoprotein on rabbit model of atherosclerosis. Proanthocyanidin and its compositions significantly alleviated the damage of vascular endothelial cell and reduced the lipid droplet in hepatic tissue and aortic tissue. CONCLUSION The proanthocyanidins and its compositions have protective effects on atherosclerosis by protecting vascular endothelial cell and reducing lipid deposition in blood vessel.