Effect of Xianghuahuru Gels on Mammary Hyperplasia Rats

OBJECTIVE To study the Xianghuahuru gels effect on the level of progesterone, estradiol in blood serum of the mammary hyperplasia rats, and morphologic change on pathological tissue of mammary gland. METHODS The model of mammary hyperplasia was established with estradiol benzoate and progesterone, and the administration time was 25 d. The changes of the third nipple diameter and pathological tissue of mammary gland on morphologic change were observed, and the estrogen(E₂), pregnancy(P) of serum were determined. RESULTS The high-dose treatment group of Xianghuahuru gels could siginificantly reduce the level of E₂(P<0.05), raise the level of P(P<0.05), and reduce the diameter of the third nipple in rat mammary gland hyperplasia models(P<0.01), besides, the high dose treatment group of Xianghuahuru gels could ameliorate the pathological tissue of mammary gland on morphologic change. CONCLUSION Xianghuahuru gels againsts rat cyclomastopathy is related to adjusting the level of sex hormones and ameliorating the pathological tissue of mammary gland.