Clinical Use of Raltitrexed

OBJECTIVE To analysis the clinical application situation of raltitrexed and seek for the method for the rational use of raltitrexed. METHODS Through search the clinical document literature of raltitrexed to summarize the published clinical data. RESULTS Raltitrexed (3 mg·m^-2) has good effect on colorectal cancer and malignant pleural mesotheliomaand. Single-agent of raltitrexed first-line treatment efficacy is twice the second-line therapy. The olds and children need reduce the dosage. Although the adverse drug reactions of raltitrexed are relatively less, the transient transaminase lifts need to be paid more attention. CONCLUSION It makes sense to select rational dosage and usage based on patient, disease condition and patient’s physical quality in order to achieve the best clinical efficacy.