Effect of Qibai Pingfei Capsules on Cytokines in Rats with COPD

OBJECTIVE To investigate the effects of Qibai Pingfei capsules on the expression of cytokines in rats with chronic obstructive pulmonary disease(COPD) and to explore its possible mechanisms. METHODS The rats were randomly divided into six groups, including normal group, COPD model group, Qibai Pingfei capsules (0.72, 1.44, 2.88 g·kg^-1) treated groups and Guben Kechuan tablets (1.44 g·kg^-1) group. Complex factors were used to make COPD model and at the same time Qibai Pingfei capsules were used daily via lavage for 4 weeks. The interleukin (IL)-8, tumor necrosis factor (TNF)-α level in serum were determined by radioimmunity, lung samples were taken to examine the degree of COPD by HE stain and immuninochemistry of ICAM. Moreover, TNF-α mRNA expression was detected by RT-PCR technology. RESULTS Compared with the model group, Qibai Pingfei capsules (1.44, 2.88 g·kg^-1) treated groups not only significantly reduced histopathological change, but also effectively prevent the level of IL-8, TNF-α, ICAM. CONCLUSION The protective effect in COPD rats of Qibai Pingfei capsules may be associated with its action of alleviate the airway inflammation by controlling the level of IL-8 and TNF-α.