Research Progress of Chiral Amino Epoxide-The Important Intermediate of HIV Protease Inhibitors

Peptide analogue HIV protease inhibitors are the main drugs for clinical treatment of AIDS. They have a common structural segment (2R, 3S)-3-amino-4-phenyl-2-butanol, which is synthesized by chiral amino epoxide. In this review, the recent research process in the synthesis methods of this key intermediate is summarized.