Study on Glyceryl Behenate as a Lubricant in Tablets

OBJECTIVE Study on glyceryl behenate as a lubricant in tablets. METHODS Glyceryl behenate was mixed with lactose, calcium hydrophosphate, or microcrystalline cellulose, the flowability of blend was tested. Making tablets with these blends, recording the ejection force, and comparing the disintegration time of lactose tablets with 2% glyceryl behenate and 0.5% magnesium stearate, respectively. RESULTS If glyceryl behenate was mixed with lactose, calcium hydrophosphate, or microcrystalline cellulose, the angle of repose would decrease. And the ejection force of lactose, microcrystalline cellulose tablet would be low(<6 kg). Preparing parameter, such as blending speed, blending time or press speed had little effect on the disintegration time of lactose tablets with glyceryl behenate as lubricant, which was quite different from magnesium stearate. CONCLUSION Glyceryl behenate is a stable lubricant.