Study on the Intestinal Absorption Kinetics of Danshensu in Rats

OBJECTIVE To study the absorption kinetics of Danshensu in the small intestine. METHODS A method was developed for the determination in rat intestinal reflux, HPLC was used for the determination of drug concentrations, UV spectrophotometry was used for the determination of phenol red concentration. RESULTS pH of intenstinal fluid had no effect on the absorption of Danshensu. The concentration range of 2-16 μg·mL^-1 had no significant effect on the maximum absorption rate and the absorption rate constant. The absorption rate of different parts of salvia intestinal was as follows: duodenum> jejunum> colon> ileum. CONCLUSION The absorption of Danshensu in the intestine is a dynamic process, the mechanism is passive diffusion, and the absorption in the colon and ileum is better.