Influecnce of Bailing Capsule on the Activity of VEGF and Inflammatory Factor of The Diabetic Nephropathy Patients with Peritoneal Dialysis

OBJECTIVE To explore the influence of the activity of vascular endothelial cell growth factor(VEGF), and the activity of inflammatory factor through clinical randomized controlled trials on patients with peritoneal dialysis by administration of Bailing capsule. METHODS According to randomized table, 52 diabetic nephrology patients who accept continuous ambulatory peritoneal dialysis for one month or more in our hospital were divided into Bailing capsule group and control group. The variation of the activity of the VEGF, inflammatory factor in serum and in dialysate was tested by ELISA before and after administration of the drug for one month. RESULTS In Bailing capsule group, the activity of the VEGF in serum and in dialysate after administration of the drug was significantly decreased compared with that before administration( P <0.01). In Bailing capsule group, the inflammatory factor was significantly decreased( P <0.05). The activity of VEGF in serum and in dialysate of Bailing capsule group significantly decreased compared with that in the control group( P <0.01). CONCLUSION Bailing capsule can reduce VEGF activity and inflammatory factors content in serum and in dialysate of peritonel dialysis patients, and can improve slightly inflammatory state.