Application of Multi-unit Modified Drug Delivery Systems in Compound Preparation

The compound preparations are composed by two or more pharmaceutical ingredients, which can enhance the drug effect significantly through synergistic and additive effect or being antagonistic to side effect compared with prescribed preparation. The multi-unit modified release drug delivery system was used in compound preparation to flexibly adjust the release program and play an all-round, multi-target and multi-link role to improve drug bioavailability and reduce side effects. In this article, the principles of several common compound preparations such as analgesic, anti-infective, hypoglycemic and antihypertensive drug and traditional Chinese medicine compound preparations were summarized. The advantages of multi-unit modified release drug delivery system applied in the compound preparation were emphasized in order to provide new ideas to the clinical development of compound preparation.