Mice Acute Toxicity of Siegesbeckia and Its Effect on Mouse Acute Gouty Arthritis

OBJECTIVE To study the mouse acute toxicity of both ethanol extract and water extract from siegesbeckia and their effects on mouse acute gouty arthritis. METHODS Bliss method was used to calculate the LD₅₀ of siegesbeckia extracts, and the mouse acute gouty arthritis model induced by sodium uric acid was observed. RESULTS LD50 of ethanol extract and water extract from siegesbeckia were 267.00 g·kg^-1 and 147.91 g·kg^-1, respectively. The joint swelling degrees of acute gouty arthritis mouse 24 h after the modeling were (0.134 8±0.049 3), (0.098 0±0.034 0) and (0.117 2±0.024 0) mL for model group, ethanol extract group and water extract group, respectively. CONCLUSION The acute toxicity of ethanol extract from siegesbeckia is significantly lower than the water extract, and the effect of ethanol extract on mouse acute gout joint swelling induced by sodium uric acid is better than water extract.