Efficiency of Tuiyin Decoction Combined with NB-UVB Irradiation in Treating Psoriasis

OBJECTIVE To determine the clinical efficiency and safety of Tuiyin decoction combined with NB-UVB irradiation in treating psoriasis. METHODS One hundred and twenty-six patients with psoriasis were divided into 3 groups. In treating group with 42 cases, Tuiyin decoction 200 mL was orally given twice a day, and combined with NB-UVB irradiation twice per week with an initialed dose of 0.5 J·cm^-2 and increasing the dose with 10%-20% per time till the erythema appeared with 3 months treating course. In control group Ⅰ with 42 cases, only taken Tuiyin decoction, and in control group Ⅱ with 42 cases, only NB-UVB irradiation was applied for 3 months treating course. RESULTS The efficiency in treatment group, control group Ⅰ and control group Ⅱ were 95.24%, 80.95%, 73.81%, respectively. The difference between the treatment group and the two control groups was statistically significant(P<0.05 or P<0.01), and the difference between the two control group Ⅰ and Ⅱ was not statistically significant. The PASI improvement rates of the combination treatment at the 4th week, the 8th week and the 12th week were all higher than that of the control groups. The patients in psoriasis guttata was better than in plaque type, efficiency of the patients in active stage was remarkably higher than that in rest stage. The onset time of the treatment group was significantly shorter than that in control groups, and the difference was statistically significant(P<0.01). But the control group I compared with control group II, the difference was not statistically significant. CONCLUSION Tuiyin decoction combined with NB-UVB irradiation is clinically effective and safe in treating psoriasis.