Determination of 10 Elements in Vacant Gelatin Capsules by ICP-MS

OBJECTIVE To establish a method for the determination of 10 elements such as V, Cr, Mn, Ni, Cu, As, Sr, Cd, Ba and Pb in vacant gelatin capsules by inductively coupled plasma-mass spectrometry(ICP-MS). METHODS The samples were digested by microwave, and ten elements were determined by ICP-MS simultaneously. RESULTS The detection limit ranges of 10 hazard elements were 0.011-0.203 ng·mL^-1, the method had good linear correlation(r>0.999), and the average recoveries were in the range of 85%-115% with RSD less than 10%. CONCLUSION This method is accurate, sensitive, convenient, and can be used to analyse the multi-elements in vacant gelatin capsules