Preparation of Hydrochlorothiazide Inclusion Compound Micro-porous Osmotic Pump Tablets

ABSTRACT: OBJECTIVE To prepare hydrochlorothiazide-hydroxypropyl-β-cyclodextrin inclusion complex micro-porous osmotic pump tablets. METHODS The HCTZ-HP-β-CD inclusion compound prepared by acid-base neutralization was characterized by infrared spectroscopy (IR) and nuclear magnetic resonance (NMR). Using accumulative drug release rate as the key index，single factor experiments were carried out to optimize such factors as the coating membrane formulation. The release in vitro of the optimized formulation was fitted to different models. RESULTS Hydrochlorothiazide inclusion compound micro-porous osmotic pump tablets obeyed the zero-order release mode in 12 hours and the cumulative release over 90%.CONCLUSION The HCTZ-HP-β-CD inclusion compound micro-porous osmotic pump tablets could deliver drug constantly for 12 h based on the intermediat of HCTZ-HP-β-CD inclusion complex.