Study on Pharmacokinetics of Astilbin Solid Dispersion in Rat

OBJECTIVE To study the pharmacokinetics of astilbin solid dispersion in rat. METHODS HPLC was used to determine the astilbin concentration in the plasma of rats. The pharmacokinetic parameters were calculated with Kinetica software. RESULTS After the rats were orally administrated with astilbin solide dispersions, the pharmacokinetic process of astilbin in rats was found to be consistent with the two-compartment model. The AUC_{0-480 min} was (1.98±0.60)mmol·min·L^-1. CONCLUSION The astilbin in solid dispersion can greatly improve its bioavailability in rat.