Protective effect of Telmisartan against Oxidation-reduction Disequilibrium of vascular endothelial cell induced by Angiotensin ⅡZHENG Shi-ming,HUANG Han-hui,LIU Shao-zhi,LIANG Ying,Zhang Xin, YAN Peng-ke

ABSTRACT：OBJECTIVE To explore the effect of angiotensin Ⅱ on oxidation-reduction equilibrium system of vascular endothelial cell and antagonism of Telmisartan. METHODS After primary cultured on 35mm glass bottom cell culture dishes, the Human vascular endothelial cell randomly divided into 5 experimental groups which were blank control group, angiotensin II model group and three different concentration of telmisartan in treatment groups(60μg/L、300μg/L、1000μg/L).Each group contents 42 samples. The concentration of MDA and the activity of SOD in vascular endothelial cell were detected in different sampling time. RESULT The concentration of MDA was proliferate instantaneous and the activity of SOD was restrained after Ang II stimulation.The Vascular endothelial cells after Telmisartan pretreatment can significantly resist the oxidative stress induced by Ang II. Furthermore, the time-dosage dependent relationship existed in the protection of Telmisartan. CONCLUSION Telmisartan can resist the oxidative stress induced by Ang II.