Influence of Antioxidant Effective Fraction of Furong Plum on the D-galactose Induced Subacute Aging Mice

ABSTRACT: OBJECTIVE To observe the total polyphenols extract of Furong Plum on the D-galactose induced subacute aging model SOD、GSH-Px activity and MDA content. METHODS 60 Kunming mice ,male,randomly divided into six groups,namely control group,model group, positive control group,low dose group,middle dose group,high dose group. positive control group were given vitamin E soft capsule in 100mg·kg-1?d-1. low dose group,middle dose group,high dose group were given the total polyphenols of Furong Plum in 100 mg?kg-1?d-1、200 mg?kg-1?d-1、300 mg?kg-1?d-1 respectively. control group and model group were given the same volume of physiological saline.once a day,for gavage 42 days.At the same time, model group and dose group mice were injected daily neck back D-galactose in 125 mg?kg-1?d-1.Control group injected with physiological saline. RESULTS The total polyphenols extract of Furong Plum can significantly enhance serum SOD activity and decrease MDA content. Also significantly enhance liver and brain tissue SOD、GSH-Px activity and decrease MDA content. Compared with model group, P < 0.05. CONCLUSION Different dosages of the total polyphenols extract of Furong Plum can antagonism free radical damage,has the function of antioxidation to delay senility. The possible mechanism is through the increase in the activity of antioxidant enzymes and reduce lipid peroxide formation, improve organism the oxidation resistance consequently.