Formulation Optimization and the Release Mechanism of Garcinia Glycosides Sustained-release Tablets

OBJECTIVE To prepare the garcinia glycosides sustained-release tablets and study drug release mechanism in vitro. METHODS Garcinia glycosides sustained-release tablets were prepared using hydroxypropylmethyl cellulose(HPMC) as gel matrix material, ethyl cellulose (EC) as skeleton material, lactose as filler and so on. The formulation was optimized using orthogonal experimental design. DDslover software was used to fitting drug release curve. RESULTS Garcinia glycosides sustained-release tablets had good sustained-release profile. The release behavior of the tablets in vitro followed Higuchi equation. It was the synergies of diffusion and dissolution and the main mechanism of drug release was diffusion for fitting well with Higuchi equation, r=0.999 3(1-12 h). CONCLUSION The garcinia glycosides sustained-release tablets prepared meet the release requirement in vitro.