Effect of Curcumin on Hemorrheology, Platelet Aggregation, Anti-oxidation and Fibrinoly System of Hyperlipidemic Rabbit

OBJECTIVE To observe the effects of curcumin on hemorrheology, platelet aggregation, anti-oxidation and fibrinoly sestem of hyperlipidemic rabbits. METHODS Forty-eight rabbits randomly divided into 6 groups which including normal control, model, curcumin(10, 20, 40 mg·kg^-1) and Xuezhikang(32.5 mg·kg^-1) groups. After 8 weeks of high-fat food and 6 weeks of treatment of curcumin, blood rheology and oxygen free radical were measured in rabbits. RESULTS Blood reduction viscosity, red cell rigidity index and deformation index of the rabbit had the tendency of decrease. Curcumin also could inhibit the platelet aggregation, which induced by ADP and collagen. The levels of rabbit serum t-PA and MDA were lower, SOD was higher in curcumin group than that in hyperlipidemia group(P<0.01). CONCLUSION Curcumin can improve the hemorrheology of the hyperlipidemic rabbits. It possessed the ability of anti-oxidation and can improve the fibrinolsis system.