Comparison of Rivaroxaban and Low Molecular Heparin on Complications after Hip Replacement

OBJECTIVE To compare the prophylactic effects of rivaroxaban and low molecular heparin on deep vein thrombosis(DVT) after hip replacement. METHODS All of 126 patients were divided into two groups randomly. Low molecular heparin group(n=70) were given low molecular heparin 40 mg before 12 h or after 24 h of hip replacement, ic, then qd, for 14 d. Rivaroxaban group(n=56) were given rivaroxaban 10 mg after 6-8 h of hip replacement, po, qd for 35 d. The postoperative bleeding and postoperative flow in the two groups were observed. The safety index and incidence of postoperative DVT were compared. RESULTS There were no significant differences of the amount of bleeding, the flow during operation, and the incidence of DVT among the two groups(P>0.05). There was significant difference of postoperative bleeding, incision infection, incision healing rate of the two groups(P<0.05), which showed that rivaroxaban group were higher than low molecular heparin group. CONCLUSION Rivaroxaban has similar effect of preventing DVT after hip replacement with low molecular heparin, but the incidence of complication is higher than low molecular heparin. Thus, the safety usage of rivaroxaban should be more researched.