Protective Effects of Lentinan Against Spleen Injury in Mice to Radiation

OBJECTIVE To study the radiation damage on mouse spleen and the protective effects of lentinan. METHODS Mouse model of chronic injury was made by exposing to 60Co g-ray which were divided into five groups: control group, model group, different doses of lentinan groups(0.02, 0.1, 0.5 mg·mL^-1). After exposing, spleen coefficient, ability of lymphocyte proliferation were checked by MTT, changes on pathology and ultramicrostructure were respectively determined. RESULTS Compared with control group, spleen coefficient, ability of lymphocyte proliferation, pathology and ultramicrostructure were damaged by 60Co g-ray in model group. Whereas, the 0.1, 0.5 mg·mL^-1 lentinan groups were uninfluenced by radiation. CONCLUSION Lentinan normalizes the injury of spleen.