Synergistic Anti-tumor activity of Sunitinib Combined with Combretastatin A-4 in SGC-7901 Cells by Apoptosis

OBJECTIVE To study the anti-cancer activity of the combination of CA-4 and sunitinib. METHODS The anti-proliferation activity of CA-4 and sunitinib were analyzed by SRB, apoptosis was detected by PI, DAPI and Western blot analysis. RESULTS The present study indicated that the combination of sunitinib and CA-4 exerted synergistic anti-proliferative effects against human gastric cancer cells SGC-7901 in vitro. The enhanced apoptosis induced by sunitinib plus CA-4 was accompanied by the greater extent of caspases-3 activation and PARP cleavage in SGC-7901 cells. CONCLUSION These findings build the rationale for further clinical development of sunitinib and CA-4 against gastric cancer (SGC-7901).