Progress of Amantadine Derivatives with Antiviral Activity

OBJECTIVE To review the research advances in amantadine derivatives with antiviral activity and to provide ideas for research and development of new anti-influenza and anti-virus drug. METHODS Review related literatures about the recent research progress on amantadine derivatives and analogs. RESULTS Many derivatives and analogs of amantadine were synthesized and their anti-influenza and anti virus activities were evaluated. The structural modification focused on the position 1 and position 2 of admantane. CONCLUSION Several active compounds are found, some of which have more potency than amantadine and rimantadine.