Determination of the Dissolution of Roxithromycin Soft Capsules by HPLC

OBJECTIVE To determine the dissolution of roxithromycin soft capsules by HPLC. METHODS The dissolution medium was acetate buffer (pH 5.5). Apparatus 2 was used with 100 r·min^-1. The dissolution medium was taken and analyzed by HPLC at 60 minutes. RESULTS It showed that the standard curve was linear in the range of 0.02-0.2 mg·mL^-1(r=0.999 9). The average recovery was 100.1%(RSD=0.6%) for roxithromycin soft capsules. The dissolutions of soft capsules from three batches were over 75%. CONCLUSION The established method can be used for determination of roxithromycin soft capsules dissolution.