Inhibitory Effects of moldavica total flavone on Airway Inflammation and Hyperresponsiveness in Ovalbumin-induced Asthmatic Rats

Objective To investigate the effects of moldavica total flavone on airway inflammation and hyperrespon- siveness in ovalbumin-induced asthmatic rats. Methods The cough model in rats and asthma model in cavies were made by using ammonia water and histamine-acetylcholine chloride to observe the antitussive and antiasthmatic actions. The inhibitory effect on airway inflammation and hyperresponsiveness in ovalbumin-induced asthmatic rats were observed. Resluts The moldavica total flavone in middle and high dose group could extend the cough latent period in rats(P<0.05 or 0.01) and gasp latent period in cavies (P<0.01), decreased the levels of serum ovalbumin specific IgE (P<0.01) and eosinophil counts in bronchoalveolar lavage fluid (P<0.01), attenuate the contraction of tracheal smooth muscle in ovalbumin-induced asthmatic rats (P<0.05 or 0.01). Conclusion 　 Moldavica total flavone has antitussive and antiasthmatic actions and may inhibit ariway inflammation and hyperresponsiveness in asthma.