Clinical Effects of Combination Therapy of Low-molecular-weight Heparin and Aspirin on Patients with Transient Ischemic Attack of Arterial Originated

OBJECTIVE To assess effects of combination therapy of low-molecular-weight heparin(LMWH) and aspirin(ASA) in transient ischemic attack(TIA) of arterial originated. METHODS With ABCD3 score, 186 cases of TIA of arterial origin were classified into three risk groups(low, moderate and high). Furthermore, three risk groups were randomized into treatment group and control group separately. The control group were treated with ASA 100 mg once daily and ozagrel 160 mg iv gtt. The treatment group was added with LMWH 0.4 mL twice daily subcutaneous injection, within 10 days. Therapeutic effect was observed with control rate of TIA and incidence of acute ischemic stroke(AIS) within 1 month. RESULTS There were no significant differences in control rate of TIA and incidence of AIS in 1ow risk group. The control rate of TIA in moderate and high risk groups were higher in the treatment group than in control group significantly. Incidence of AIS in moderate and high risk groups was lower in the treatment group than in control group significantly at 1 month. No major hemorhagic complications were observed. CONCLUSION The combination of ASA and LMWH in TIA patients with moderate and high ABCD3 score could be more effective than ASA monotherapy.