Meta-analysis of tranexamic acid in the treatment of Idiopathetic menorrhagia

Objective To review the quality of studies about the treatment of tranexamic acid in idiopathetic menorrhagia systematically and meta-analyze the effect of tranexamic acid on idiopathetic menorrhagia. Methods Collected all the studies about the treatment of tranexamic acid in idiopathetic menorrhagia, then evaluated their qualities by using the Jadad scale. Finally, compared the efficacy and safety of tranexamic acid with placebo, progesterone and non-steroidal drugs in the treatment of idiopathetic menorrhagia. Results According to the inclusion and exclusion criteria, a total of eight articles were include in this study, seven of them were English literatures and one was Chinese. The proportion of high quality articles was 87.5%. All the drugs used in these articles could reduce the bleeding of patients with idiopathetic menorrhagia. However, on the reduction in loss, treatment efficiency and the improvement ratio of patient feel, the effect of tranexamic acid was significantly higher than placebo and other drug group. Tranexamic acid didn’t change the length of the patient's menstrual period, and the proportion of adverse reactions was significantly lower than progesterone drugs. Conclusion Tranexamic acid is a safe and effective drug for the treatment of idiopathetic menorrhagia. However, because the number of literatures rolled in this study was small, there is a certain bias, which needed further research.