Preparation of Ganciclovir Self-microemulsifying System by Temary Phase Diagram Method

OBJECTIVE To evaluate the optimum formulation for the self-emulsifying drug delivery systems of ganciclovir. METHODS The formulation of the self-emulsifying drug delivery system of ganciclovir was optimized by studying the pseudo-ternary phase diagram, the solubility, and particle size. Ganciclovir was successfully embedded in the SEDDS emulsion. RESULTS Ganciclovir preparation of self-microemulsion was oil phase of IPM, surfactant cremophor RH40, co-surfactant of PEG 400 (1∶1.5∶1.5). CONCLUSION The preliminary ganciclovir self-microemulsifying prepartion is successfully prepared.