Influence of Hexapeptide on Rabbit Platelet Aggregation Activity

OBJECTIVE To investigate the effect of hexapeptide on platelet aggregation activity in rabbit. METHODS The blood of rabbit carotid artery was taken, and then, the anticoagulation blood was obtained by adding sodium citrate into the whole blood. The platelet aggregation rates induced by different inducers were determined by turbidimetry. RESULTS The aggregation inhibition rates of 1×10^-5 mol·L^-1 hexapeptide induced by ADP, arachidonic acid and thrombin in rabbit, were (66.22±1.40)%, (67.94±2.32)% and (58.18±4.67)%, respectively. The IC₅₀ of aggregation inhibition rates of hexapeptide in rabbit induced by ADP, arachidonic acid and thrombin, were 3.24×10^-6 mol·L^-1, 1.32×10^-6 mol·L^-1 and 7.24×10^-6 mol·L^-1, respectively. CONCLUSION Hexapeptide has the effect of anti-platelet aggregation in rabbit in vitro.