Pharmacokinetics of Linezolid in Ocular Cornea of Rabbit

OBJECTIVE To study pharmacokinetics of linezolid in ocular cornea of rabbit after ocular instillation. METHODS Forty New England rabbits were topically applied 50 mL of linezolid eye drops. Ocular cornea was sampled at different intervals after drug instillation, and the drug levels were assayed by HPLC. The pharmacokinetics parameters were figured out by DAS 2.1.1 process. RESULTS The peak concentration of linezolid in cornea was (58.62±15.48)μg·g^-1 in 0-120 h. The t_1/2 was (38.09±11.59)h. The AUC_0-t was (2 459.02±508.95)μg·h·g^-1, and AUC_0-∞ was (2 834.13±578.96)μg·h·g^-1. CONCLUSION Linezolid has a good pharmacokinetics character and permeability in ocular cornea of rabbit.