Preparation and Content Determination of Osthole Aquogel Suppository

OBJECTIVE To preparation of osthole aquogel suppository and to establish its assay method. METHODS The optimal formula was optimized by orthogonal experiment and the content of osthole aquogel suppository was determined by HPLC. RESULTS The optimized formula was as follows: sodium alginate 0.4 g, Tween-80 2.4 g, glycerol monostearate 1.2 g, carbomer 0.4 g. With the optimal formula, the content of osthole in 3 batches of suppositories were 13.23, 13.95, 13.19 mg, respectively. CONCLUSION The design of the formula is reasonable, the method for assaying is simple, fast and accurate.