Comparison of Effects of Losartan and Valsartan on Essential Hypertension Complicating Hyperuricemia

OBJECTIVE To evaluate the effect of losartan and valsartan on blood pressure and serum uric acid in patients with essential hypertension complicating hyperuricemia. METHODS Sixty patients with essential hypertension complicating hyperuricemia were randomized into losartan group(n=30) and valsartan group(n=30). The losartan group was treated with 50 mg·d^-1 losartan and the valsartan group was treated with 80 mg·d^-1 valsartan for 8 weeks respectively. The dosages were added to 100 mg·d^-1 and 160 mg·d^-1 respectively from 4th week if the patients’ blood pressures were not well controlled. The blood pressure and serum uric acid were compared between the two groups before and after treatment. RESULTS Losartan group and valsartan group both had nearly good effect on reducing blood pressure(P>0.05). Compared with prior treatment, serum uric acid after treatment in losartan group was decreased significantly(P<0.05), while in valsartan group it had no statistical significance(P>0.05). CONCLUSION Losartan is a better medication for patients with essential hypertension complicating hyperuricemia.